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1,2,4-Triazole

CAS No.
288-88-0
Chemical Name:
1,2,4-Triazole
Synonyms
TA-4;TAR4;TAR6;TAAR6;TaR-4;TaR-6;TRIAZOLE;CGA-71019;s-Triazole;pyrrodiazol
CBNumber:
CB2277901
Molecular Formula:
C2H3N3
Formula Weight:
69.07
MOL File:
288-88-0.mol
MSDS File:
SDS

1,2,4-Triazole Properties

Melting point
119-121 °C (lit.)
Boiling point
260 °C (lit.)
Density
1.15 g/cm3 (130℃)
refractive index
1.4854 (estimate)
Flash point
140 °C
storage temp.
Store below +30°C.
solubility
547g/l
pka
2.27(at 20℃)
form
Crystalline Powder and Flakes
color
White
PH
8 (10g/l, H2O, 20℃)
Water Solubility
1250 g/L (20 ºC)
Merck
14,9605
BRN
104767
InChIKey
NSPMIYGKQJPBQR-UHFFFAOYSA-N
CAS DataBase Reference
288-88-0(CAS DataBase Reference)
EWG's Food Scores
FDA UNII
NIST Chemistry Reference
Pesticides Freedom of Information Act (FOIA)
,
EPA Substance Registry System

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H319-H361d-H361
Precautionary statements  P201-P280-P301+P312a-P405-P501a-P281-P305+P351+P338
Hazard Codes  Xn,Xi,C
Risk Statements  22-36-63-34
Safety Statements  36/37-45-36/37/39-27-26
WGK Germany  2
RTECS  XZ3806000
Hazard Note  Irritant
TSCA  Yes
HS Code  29339990
Toxicity LD50 orally in Rabbit: 1650 mg/kg LD50 dermal Rabbit 3129 - 4200 mg/kg

1,2,4-Triazole price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T46108 1,2,4-Triazole 98% 288-88-0 25g $31.6 2021-12-16 Buy
Sigma-Aldrich 8.08388 1,2,4-Triazole for synthesis 288-88-0 25 g $38.57 2021-12-16 Buy
Sigma-Aldrich T46108 1,2,4-Triazole 98% 288-88-0 100g $83.6 2021-12-16 Buy
Sigma-Aldrich 8.08388 1,2,4-Triazole for synthesis 288-88-0 100 g $123.02 2021-12-16 Buy
Sigma-Aldrich 8.08388 1,2,4-Triazole for synthesis 288-88-0 25 kg $1220 2021-12-16 Buy
Product number Packaging Price Buy
T46108 25g $31.6 Buy
8.08388 25 g $38.57 Buy
T46108 100g $83.6 Buy
8.08388 100 g $123.02 Buy
8.08388 25 kg $1220 Buy

1,2,4-Triazole Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder and flakes

Uses

1,2,4-Triazole is present in a large variety of fungicides as C14-demethylase-inhibitors. In addition they are used in synthetic chemical reactions such as the design and preparation of ghrelin receptor ligand antagonists, like JMV 2959.

Uses

1,2,4-Triazole is used in the production of pesticides, pharmaceuticals (fluconazole), dyes and rubber additives, and also in the photoconductor of replication system. Intermediate of antifungal fluconazole.

Uses

1,2,4-triazole and its derivatives are important structural moieties of many pharmaceutical drugs. Triazoles can also act as ligands to form coordination complexes with transition metal ions. Due to their electron-deficient nature, they exhibit excellent electron-transport and hole-blocking properties, making them promising organic materials in material science applications.

Definition

A heterocyclic organic compound with a five-membered ring containing two carbon atoms and three nitrogen atoms. There are two isomers.

Definition

1,2,4-triazole is a chemical substance with molecular formula C2H3N3, molecular weight 69.07 and CAS No. 288-88-0. Colorless acicular crystal, soluble in water and ethanol. 1H-1,2,4-triazole is a 1,2,4-triazole. It is a tautomer of a 3H-1,2,4-triazole and a 4H-1,2,4-triazole.
Triazole is an aromatic five membered heterocyclic compound. Its unique structure is conducive to the formation of a variety of non covalent bonds and is easy to promote the binding of proteins, enzymes and receptors, thus showing a wide range of biological pharmacological activities, such as anticancer, antispasmodic, antibacterial, anti HIV. In particular, 1,2,3-triazole has strong thermal stability and acid-base stability, and is not sensitive to redox, hydrolysis and enzymatic degradation. It is often used as a pharmacodynamic group in drug synthesis.

Chemical Synthesis

Alkyl bromide and sodium azide were used as raw materials to prepare organic azides, and a series of 1,2,3-triazole small molecules were prepared by click chemistry. The structures of the six products were characterized by 1H NMR, 13C NMR and IR. the products were expected targets. Furthermore, the effect of different substituent structure on the reaction was discussed. Especially the introduction of drug molecule ethisterone, which is expected to provide a certain experimental basis for the application of triazole and its derivatives in biomedicine and other fields.
synthesis route of 1,2,4-Triazole.pngAs shown in the figure, alkyl bromide and sodium azide were used as raw materials, N, N-dimethylformamide was used as solvent, and reacted at room temperature for 20 hours under the protection of nitrogen. After the reaction, the solvent was extracted, dried, filtered and spin evaporated to obtain alkyl azide compound 1.Put a certain proportion of alkyl azide 1 and alkynyl compound 2 into a round bottom flask, copper powder and copper acetate as catalysts, acetonitrile as solvent, and react at room temperature for 4 hours under the protection of nitrogen. After that, extract, dry, filter and spin the solvent, and purify by thin chromatography to obtain triazole compound 3.

Purification Methods

Crystallise 1,2,4-triazole from EtOH, H2O, EtOAc (m 120.5-121o), or EtOH/*C6H6. The hydrochloride has m 170o, and the picrate has m 163-164o (from H2O or CHCl3). [Barszcz et al. J Chem Soc, Dalton Trans 2025 1986]. [Beilstein 26 H 13, 26 II 6, 26 III/IV 35.]

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View Lastest Price from 1,2,4-Triazole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-04-22 1,2,4-Triazole
288-88-0
US $12.00 / kg 1kg 99% 10tons Henan Guange Biotechnology Co. LTD
2022-03-08 1,2,4-Triazole
288-88-0
US $30.00 / KG 1KG 99.9% 100MT/Month Wuhan wingroup Pharmaceutical Co., Ltd
2022-02-25 1,2,4-Triazole
288-88-0
US $10.00 / KG 1KG 99% 500tons/month Shanxi Naipu Import and Export Co.,Ltd
  • 1,2,4-Triazole
    288-88-0
  • US $12.00 / kg
  • 99%
  • Henan Guange Biotechnology Co. LTD
  • 1,2,4-Triazole
    288-88-0
  • US $30.00 / KG
  • 99.9%
  • Wuhan wingroup Pharmaceutical Co., Ltd
  • 1,2,4-Triazole
    288-88-0
  • US $10.00 / KG
  • 99%
  • Shanxi Naipu Import and Export Co.,Ltd
TA-4 PYRRODIAZOLE TRIAZOLE TRIAZOLE(1,2,4-) 1H-1,2,4-TRIAZOLE 1-HYDRO-1,2,4-TRIAZOLE 1,2,4-1H-TRIAZOLE 4H-1,2,4-triazole   CGA-71019 s-Triazole 1,2,4-TRIAZOLE, 1GM, NEAT 1,2,4-TriazoleForSynthesis 1,2,4-Triazole,99% 1,2,4-1H-Triazole, 99.50% 1,2,4-1H-Triazole, flakes, 99+% AKOS BBS-00004410 pyrrodiazol 1H-1,2,4-TRIAZLOENA-1,2,4-TRIAZLOE K-1,2,4-TRIAZLO 1H-1,2,4-Triazole (1,2,4-1H-Triazole sym-triazole 1,2,4-TRIAZOLE pure Voriconazole Impurity 7 1H-1,2,4-Triazole≥ 99% (HPLC) 1,2,4-1H-Triazole s-Triazole Pyrrodiazole 1H-1,2,4-Triazole 1,2,4-Triazol   1,2,4-1H-TRIAZOLE, 99+%, FLAKES 1,2,4-1H-TRIAZOLE, 99.5% 1,2,4-1H-Triazole, flakes 1H-1,2,4-Triazol   1.2.4-Triazole 1g [288-88-0] Triazole-[13C2,15N2] 1,2,4-Triazole 4-1H-Triazole 1,2,4-1H-Triazole, 99.5% 25GR 1,2,4-1H-Triazole, 99.5% 5GR 3,4-Diazapyrrole s-Triazole (8CI) 1,2,4- threetriazole 1,2,4-1H-Triazole, 99.5%, 99.5% 1, 4-trichlorobenzene three azole nitrogen Anti-TAAR6 antibody produced in rabbit TAAR6 TAR4 TaR-4 TAR6 TaR-6 1,2,4-Triazole Vetec(TM) reagent grade, 98% 1,2,4-1H-TriazoL Fluconazole Impurity 16 1,2,4-Triazole > 1,2,4-Triazole, 99%, reagent grade 1,2,4-Triazole @100 μg/mL in MeOH 1,2,4-TRIAZOLE FOR SYNTHESIS 25 G 1,2,4-Triazole fandachem 1, 4-trichlorobenzene triazole 1,2,4-Triazole USP/EP/BP 1,2,4 Triazole LR 288-88-0