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ChemicalBook >> CAS DataBase List >>(S)-(+)-2-Amino-3-methyl-1-butanol

(S)-(+)-2-Amino-3-methyl-1-butanol

CAS No.
2026-48-4
Chemical Name:
(S)-(+)-2-Amino-3-methyl-1-butanol
Synonyms
H-VAL-OL;L-Valino;L-Val-ol;-(+)-VaL;H-VALINOL;L-VALINOL;L-VALINAL;L-Valanol;S-VALINOL;H-L-VAL-OL
CBNumber:
CB9319657
Molecular Formula:
C5H13NO
Formula Weight:
103.16
MOL File:
2026-48-4.mol
MSDS File:
SDS

(S)-(+)-2-Amino-3-methyl-1-butanol Properties

Melting point
30-34 °C
alpha
16 º (c=10,EtOH)
Boiling point
81 °C8 mm Hg(lit.)
Density
0.926 g/mL at 25 °C(lit.)
refractive index
n20/D 1.4548(lit.)
Flash point
196 °F
storage temp.
Store at +2°C to +8°C.
form
Liquid After Melting
pka
12.82±0.10(Predicted)
color
Clear slightly yellow
optical activity
[α]25/D +10°, c = 10 in H2O
Water Solubility
Soluble in water.
Sensitive
Air Sensitive
BRN
1719137
InChIKey
NWYYWIJOWOLJNR-RXMQYKEDSA-N
CAS DataBase Reference
2026-48-4(CAS DataBase Reference)
NIST Chemistry Reference

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Hazard statements  H315-H319
Precautionary statements  P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313
Hazard Codes  Xi
Risk Statements  36-36/37/38
Safety Statements  26-24/25-36
WGK Germany  3
10-23
HazardClass  IRRITANT
HS Code  29221980

(S)-(+)-2-Amino-3-methyl-1-butanol price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.14082 (S)-(+)-2-Amino-3-methyl-1-butanol for synthesis 2026-48-4 1 mL $48.28 2021-12-16 Buy
Sigma-Aldrich 186708 (S)-(+)-2-Amino-3-methyl-1-butanol 96% 2026-48-4 1g $43.1 2021-12-16 Buy
Sigma-Aldrich 186708 (S)-(+)-2-Amino-3-methyl-1-butanol 96% 2026-48-4 5g $140 2021-12-16 Buy
TCI Chemical V0058 L-Valinol >97.0%(GC)(T) 2026-48-4 5g $99 2022-04-27 Buy
TCI Chemical V0058 L-Valinol >97.0%(GC)(T) 2026-48-4 25g $297 2022-04-27 Buy
Product number Packaging Price Buy
8.14082 1 mL $48.28 Buy
186708 1g $43.1 Buy
186708 5g $140 Buy
V0058 5g $99 Buy
V0058 25g $297 Buy

(S)-(+)-2-Amino-3-methyl-1-butanol Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

L-Valinol is used as a reagent in the synthesis of simple 1,3-thiazolidine-2-thione derivatives which can exhibit fungicidal activity. L-Valinol is also used as a reagent in the synthesis of small-molecule inhibitors of MDM2-p53 protein-protein interaction (MDM2 inhibitors) in clinical trials for the treatment of cancer.

Uses

(S)-(+)-2-Amino-3-methyl-1-butanol can be used to prepare:
  • Imines and oxazolines by reacting with aldehydes and nitriles, respectively.
  • Chiral oxazoline derived multidentate ligands containing cyclophosphazene moiety.

Purification Methods

Purify S-valinol by vacuum distillation using a short Vigreux column (p 11). Alternatively it is purified by steam distillation. The steam distillate is acidified with HCl; the aqueous layer is collected and evaporated. The residue is dissolved in butan-1-ol, filtered and dry Et2O added to crystallise the hydrochloride salt (hygroscopic), m 113o. The free base can be obtained by suspending the salt in Et2O and adding small volumes of saturated aqueous K2CO3 until effervescence is complete and the mixture is distinctly alkaline. At this stage the aqueous layer should appear as a white sludge. The mixture is heated to boiling and refluxed for 30minutes (more Et2O is added if necessary). Purification of Biochemicals — Amino Acids and Peptides The Et2O layer is decanted off from the white sludge, the sludge is extracted twice with Et2O (by boiling for a few minutes), the combined organic layers are dried (KOH pellets), evaporated and the residue is distilled in a vacuum. [Nagao et al. J Org Chem 55 1148 1990, Beilstein 4 III 805.]

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View Lastest Price from (S)-(+)-2-Amino-3-methyl-1-butanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-02-25 (S)-(+)-2-Amino-3-methyl-1-butanol
2026-48-4
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2019-07-06 (S)-(+)-2-Amino-3-methyl-1-butanol
2026-48-4
US $20.00 / KG 25KG 98% 100kg Career Henan Chemical Co
L-VALINAL (+)-L-VALINOL L-(+)-VALINOL L-VALINOL L-2-AMINO-3-METHYL-1-BUTANOL l-2-amino-3-methylbutan-1-ol H-VALINOL H-VAL-OL H-L-VAL-OL (2S)-2-AMINO-3-METHYL-BUTAN-1-OL L-Valinol ,98% (S)-2-Isopropyl-2-aminoethanol (S)-(+)-2-Amino-3-methyl-1-butanol,96% L-Valinol ,98% [ee: 95%] L-Valinol ,95% (S)-(+)-2-Amino-3-me L-Valino (S)-(+)-2-AMino-3-Methyl-1-butanol, 96% 1ML (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL FOR S (S)-(+)-2-Amino-3-methyl-1-butanol(L-Valinal) L-Valinol, 98%, ee: 95% PKC PharMaceuticals, Inc. L - valerian aMMonia alcohol L-(+)-Valinol (S)-(+)-2-Amino-3-methyl-1-butanol L-2-Amino-3-methylbutan-1-ol (S)-(+)-2-Amino-3-methyl-1-butanol 96% L-Valinol Free Base L-Valinol, ee: 95% L-Valinol≥ 98% (GC) L-Valinol,99%e.e. L-Valinol,Elvitegravir intermediate 1-Butanol, 2-amino-3-methyl-, (S)- (S)-(+)-2-Amino-3-methyl-1-butanol~H-Val-ol Valinol,97% (R)-(+)-2-Amino-3-methyl-1-butanolL-Valanol L-Valinol(S)-(+)-2-Amino-3-methyl-1-butanol L-Valanol (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL, 96% (95% EE/GLC) L-Val-ol (S)-2-AMINO-3-METHYL-1-BUTANOL 98.0% 1-Butanol, 2-amino-3-methyl-, (2S)- S-VALINOL (S)-2-AMINO-3-METHYL-L-BUTANOL (S)-(+)-2-AMINO-3-METHYL-BUTANOL (S)-2-AMINO-3-METHYL-BUTAN-1-OL (S)-(+)-2-AMINO-3-METHYL-1-BUTANOL (S)-2-AMINO-3-METHYL-1-BUTANOL S-(-)-2-AMINO-3-METHYL-1-BUTANOL H-Val-ol (S)-(+)-2-Amino-3-methyl-1-butanol) (S)-(+)-2-Amino-3-methyl-1-butanol fandachem -(+)-VaL (S)-(+)-2-Amino-3-methyl-1-butanol USP/EP/BP 2026-48-4 2046-48-4 226-48-4 AMINE Peptide Synthesis Specialty Synthesis Organic Building Blocks